“Mood disorders” like bipolar are a modern way of understanding human behavior – there is nothing in the ancient texts about that, just like there is nothing about cars or iPhones or the United States.
But we can see in the suttas that a serial killer who wore fingers around his neck became an arhant. As did Patacara, who ran around naked and howling with grief. There are many people who heard voices and experienced visions who attained awakening – the Buddha being one of them. And of course the Buddha also experienced extreme states of consciousness – like jhana – which he learned to use in service of the path.
What would a psychiatrist say about these people? It would be a severe diagnosis, no?
Since we are discussing a general question about awakening and “mood disorders” let me answer with a general answer. This is not meant as personal advice for anyone.
The idea that bipolar or even schizophrenia are lifelong illnesses, requiring lifetime medication, is actually quite controversial. While certain psychic realities have genetic correlates, this is not the same as causation.
Modern ideas about medication and “mental illness” are often shaped by pharmaceutical companies who have a vested interest in the matter and a track record of dishonesty. These companies rarely, if ever, conduct longitudinal studies. To the contrary, the existing research seems to suggest that discontinuation via tapering may be better in the long-run.
Of course, any given individual’s experience may vary… but yes. I think that anyone can awaken. It is our birthright.